Studies revealed that is possible for systemic lupus erythematosus to affect the nervous system. Patients with lupus may experience confusion, difficulty with concentrating, headaches, fatigue, strokes or other signs that show nervous system involvement.
Studies suggested that the nerve tissue may be damaged when antibodies attack nerve cells or blood vessels. It is known that the nervous system requires an uninterrupted flow of blood, that is needed to supply with oxygen and nutrients its tissues. When this flow of blood is slowed or interrupted, the nervous cells are unable to function normally, and there appear symptoms. The symptoms vary, depending where the tissue injury is situated.It is good to know that the nervous system contains three parts. The central nervous system comprises the brain and spinal cord, the peripheral nervous system nerve fibers that have the role to provide the skin and muscles the power needed for sensation and movement, and the third part is the autonomic nervous system that has the role to regulate spinal, peripheral nerves and to innervate the internal organs.
An inflammation of the blood vessels of the brain that appears to 10% of all lupus patients is called the central nervous system vasculitis.This disease usually requires hospitalization and high doses of corticosteroids. Some of the symptoms that appear are high fevers, seizures, psychosis and meningitis-like stiffness of the neck. If it is not aggressively managed, the central nervous system vasculitis rapidly progresses to stupor and coma.
People with mild to moderated systemic lupus erythematosus can experience the cognitive dysfunction. That is a group of symptoms that appear at about 50% of these patients, and we can mention here fatigue, memory impairment, feelings of confusion, and difficulty to express the thoughts. By taking a neuropsychological test or a test called the positron emission tomography, these symptoms can be clearly documented.It is known that cognitive dysfunction may come and go on its own, but no optimal therapy is available. Also, it is not known which is the reason for the symptoms that appear. Dealing with a cognitive dysfunction is frustrating, and often counseling a person in developing coping skills may be helpful.
About 20% of the patients having systemic lupus erythematosus experience the lupus headache. This manifests by severe headaches, is similar to migraine and can be often seen in persons who have also Raynaud's phenomenon. As a treatment, it is useful the same one used in tension headaches or migraine, and sometimes corticosteroids.
It is known that about a third of the patients having lupus can have a false positive syphilis test, a positive anticardiolipin antibody, or a prolonged clotting time test.This is known under the name of the lupus anticoagulant or the antiphospholipid antibody. About 1/9 of the patients having lupus will develop blood clots in various parts of the body, which is called the antiphospholipid syndrome.If blood clots appear in the nervous system, they can cause a stroke, and symptoms of a stroke include the painless onset of neurologic deficits without any signs of active lupus.If a stroke appears, there must be taken blood-thinning medications. We can mention here low-dose aspirin, coumadin or heparin.
Among patients having systemic lupus erythematosus there is a percentage of 20% that have fibromyalgia syndrome as well. These patients experience increased pain in the soft tissues, tender points, and, in addition cognitive dysfunction, decreased ability to concentrate, lack of stamina and difficulty sleeping. As a treatment, we can mention anti-depressants, counseling, and physical therapy if needed.
It was discovered that medications used to treat systemic lupus erythematosus can develop symptoms like those of the central nervous system lupus.Psychosis can appear due to anti-malarials in very high doses; headache, dizziness, and in rare situations meningitis-like symptoms can be provoked by nonsteroidal anti-inflammatory drugs. Also if a patient uses corticosteroids, there can appear moods swings, psychosis, depression, agitation, confusion, if there are taken high doses can appear seizures, and anti-hypertensive medications may be associated with depression or loss of libido.
A study discovered that people that have both lupus and Sjogren's syndrome may be predisposed to develop vasculitis or cognitive dysfunction. Sometimes, circulating proteins in the blood can lead to cryoglobulinemia or hyperviscosity syndrome.Plasmapheresis or filtering the blood can ease these complications.Sometimes, pronounced decreases in platelet counts may be associated with bleeding.People with thrombotic thrombocytopenic purpura or who lack Protein S or Protein C may clot, and those with lupus, idiopathic thrombocytopenic purpura and kidney failure may bleed.
In peripheral nervous system lupus, involvement of the cranial nerves can cause visual disturbances, drooping of the eyelid(s), ringing in the ear(s), facial pain and dizziness.Symptoms of numbness or tingling in the arms or legs can appear if there is an inflammation of the blood vessels supplying the peripheral nerves. There can also appear symptoms due to other conditions than lupus and electromyogram and nerve conduction tests are usually helpful to determine if symptoms are due to some other cause. Corticosteroids are used to treat inflammation of the peripheral nerves.
It is important for your doctor to know if you experience nervous system symptoms. It is possible that these symptoms to appear due to lupus, due to a medication or a particular aspect of your life. The doctor will ask you about the symptoms you experience, he will perform a physical examination and a laboratory evaluation including a blood chemistry panel, complete blood count and urinalysis. Also, diagnostic tests like sedimentation rate, ANA, anti-DNA, anti-ribosomal P antibodies and complement may be useful in order to determine nervous system involvement.There are neurodiagnostic tests, that include CT and MRI brain scans, brain waves or electroencephalogram and spinal taps.In a few hospitals, there can also be performed PET scans.The spinal fluid may be examined for cells, protein components and antineuronal antibodies. In patients with cognitive dysfunction, neuropsychologic tests may be helpful.
The treatment for nervous system lupus depends upon its source, and can include immunosuppressants, blood thinners, antibiotics, steroids, anti-depressants, counseling or surgery. If there are evident diagnostic difficulties, a rheumatologist and/or neurologist should be involved in your care. It was seen that for many people with lupus, nervous system involvement is completely reversible.
For more resources about symptoms of lupus please review this http://www.lupus-guide.com/systemic-lupus.htm or even http://www.lupus-guide.com/lupus-rash.htm
Frequently Asked Questions
How do you have a successful birth with Anticardiolipin Antibody Syndrome?
I was diagnosed several years ago with Anticardiolipin Antibody Syndrome, after several miscarriages. Being married, and my husband wanting to try again. I am hoping to find someone with the same health issues that has had successful pregnancy's that may know certin things to do to help with a successful birth.
You should probably see a high risk OB specialist. He /she can advise you. You may need to check with a nearby university hospital.
Elevated Anticardiolipin Antibodies?
Anyone out there have elevated Anticardiolipin Antibodies? I had blood work done recently, which revealed that I have an moderately high level of IgM ACA. I will be tested again at the end of the month to confirm that it's not transiently high, but I'm not too happy about this.
If you have had this or have this, how's your health? How serious did your doctor make this out to be?
An antibody directed against cardiolipin. They are the most widely accepted and tested for immune factor. Approximately 80% of patients who have an antiphospholipid antibody problem will test positive for anticardiolipin antibodies, but the remaining 20% will test positive for one of the other six antiphospholipid antibodies. Some of these conditions can be treated with steroids, immunoglobulins, or other means.
It is used to help investigate inappropriate blood clot formation, to help determine the cause of recurrent miscarriage, or as part of an evaluation for antiphospholipid syndrome.
It sounds like you are in good hands.
Do I need to fast before blood work?
PT and PTT Activated
TSH, 3rd Generation
If so, how long? I have to go get it done tomorrow, and nobody told me whether or not to fast!
Follow the instructions provided by your doctor. If you were not specifically told to fast, it is not necessary. However if you are still concerned and would like to play it safe, typical instructions are to not eat or drink anything after midnight on the day of your visit to the doctor.
Do you know about antiphospholid blood disorders (may cause miscarriages)?
I wanted to let some people know that about a disorder that you may have if you have had multiple miscarriages. It is called antiphospholipid syndrome; aka - anticardiolipin antibody syndrome; itc. There are several names. However, this is abnormal blood clotting disorder that may be occuring if you have had 3 or more miscarriages. Some doctors do not know about this and some patients do not check for the antibodies until after having several miscarriages. I had tested positive to it a few times and negative some others. I had 3 miscarriages, none can be proven that the blood disorder was the culprit but this disorder can also be a problem for men as well, any blood cloting problem can be a problem.
yes because I have such a disorder. I have Factor V Leiden. I just wanted you to know that with proper treatment you can have a child. I have two beautiful girls. But it took lots of Lovenox injections to safety get them here. But it was well worth it. Good luck to you.
I'm freaking out - Someone please help explain this....?
So, I had my 8 week tests done and one came back abnormal. My doc said that the syphilis test came back negative but the rpr portion crossed with an antibody so they are testing me further. They took blood from me yesterday saying it was for anticardiolipin antibody and that if the test comes back negative, we do nothing. if it comes back positive, he'll put me on baby aspirin and my chances of miscarriage drop dramatically. I'm freaking out because I'm just not understanding what is going on. I've googled and that confuses me more! I'm 10 weeks now, we saw the baby yesterday and it looked wonderful, waved at me, 182bpm (he said he liked to see it that high in the first trimester) and all looked great! Has anyone heard of this testing or been through my experience?? Thanks!
ive never heard of that and im sorry i cant be much help other than to say take it easy! dont stress as that can cause your chances of a miscarriage to go up. i hope all is well with baby
Anyone out there have Antiphospholipid Syndrome?
I've been recently diagnosed with it - I have moderately high levels of IgM anticardiolipin antibody. I had a stroke at age 24, I am now 33 and have had no problems since. They told me at the time of my stroke that there was nothing wrong with me, but when I ordered my health records from back then, I saw that my IgM anticardiolipin was at 30...I saw a hematologist recently, who has checked it twice, and the first test came back at 23, the second at 20. I am now on a baby aspirin daily. Before now, I was on nothing at all.
I am worried and want to hear from anyone with this problem. How is it going for you? I'm worried that I won't have a normal life span or will have a stroke or heart attack at any moment.
I've done a lot of research on this, and most articles I read suggest that the IgM antibody's role in clotting is 'unknown' and that it is the IgG that is dangerous, but my hematologist disagrees...
That's not what I said. It IS life threatening, I've already had a stroke and open heart surgery. Also, my hematologist did NOT say that IgM is not dangerous, he said it WAS.
Also, I have no baby. I'd like to, but am being told that it is risky for me to be pregnant.
I said I'm on BABY ASPIRIN, not that I have a baby. LOL.
Back in undergrade, I took genetic. I am not a pro. I would say to keep a healthy diet and stop worrying about things that are beyond your control. The Hematologist told you that the IgM role in clotting is unknown and the IgG dangerous. You still lucky in the sense that it is not life threating. By worring about what you have can really give you another heart attack. You should be enjoying your baby and give them the love that you should be giving them. No one knows when their time is up. Sick or not we all have to go.
Take care of yourself, and enjoy your life. Find out as much as you can how you can live a healthier and better life from your doctors and your research. If you have 2 days or 20 to 100 years to live, make it the best. Surround yourself with love and most of all do the best that you can to show your kids that you love them. Life is short for all of us since none of us knows when our time is up.
I will keep you in my prayers and may the peace of God surround you and your family
Positive lab test. need help with this?
tested positive for anticardiolipin IgM antibody. It is of significance (my lab paperwork states this). However, the idiot OBGYN doctor I had who ordered this test never called me with any results and the only reason I have this information is because I requested my medical records.
I brought this to my regular doctor who is having it repeated, which is what the lab statement says.
Has anyone had this positive and what exactly are its implications?
I also tested on the high side for the following-
beta-2 glycoprotein IgA
and LOW for homocysteine
Anticardiolipin is elevated in autoimmune diseases and can cause increased clotting. These sites have additional info:
I tested positive........ what does this mean?
I tested positive for anticardiolipin IgM antibody. It is of significance (my lab paperwork states this). However, the idiot OBGYN doctor I had who ordered this test never called me with any results and the only reason I have this information is because I requested my medical records.
I brought this to my regular doctor who is having it repeated, which is what the lab statement says.
Has anyone had this positive and what exactly are its implications?
ummm firefly... read this again, as you obviously didnt read the entire thing.
Of note, my regular doctor is not familiar with this type of test, since it's very specific and not a common test.
also tested on the high side for the following-
beta-2 glycoprotein IgA
and LOW for homocysteine
I have had one (possibly 2) early miscarriages
Anti-cardiolipin antibodies include IgG, IgM and IgA. Were you tested only for the IgM? This type of testing is also called APA or Antiphospholipid antibodies. The normal range is less than or equal to I0 MPL units/mL. A low positive is 11-20 MPL units/mL, a moderate positive is 21-60 MPL units/mL and a high positive is more than 60 MPL units/mL. Did your labwork address this? This is complicated stuff. Anti-cardiolipin antibodies are a heterogeneous family of autoantibodies directed against protein–phospholipid complexes.
Antiphospholipid testing is used to help determine the cause of an unexplained thrombotic episode, recurrent fetal loss, thrombocytopenia, and/or a prolonged PTT. You're seeing an OB/Gyn so does fetal loss apply to you?
Specific antibodies can elevate with infection, for instance, but whether or not yours is a chronic significant elevation can't be determine without retesting in 8 to 10 weeks. I don't know why your antibodies were tested in the first place. Do you? Your doctor can best explain to you what this means in terms of your health. I caution you against asking for this kind of interpretation online. I suggest you continue follow up with your primary care doctor but speak to the Ob/Gyn and get your questions answered. You deserve that much.
Go ahead & email me about all your labs. I can explain them and I cannot interpret their significance. I'd have to be doctor who is familiar with your case to do that.
Do you think I really have SLE? and is Plaquenil right for me? ) Pleasssse help me!!?
I have a history (about 4 years or so) of dizzy spells, blurred and double vision, pins and needles in my face, migraines and tiredness. I went to the doctors for blood tests and it came back that I had past infections of ross river, barmah forest virus and epstein-barr. I also had an ESR of 103 and a few abnormalities in my blood but nothing else major.
I was referred to see a general physician bit didnt quite get there before I had a major seizure (followed by 2 more in hospital). I had a few tests done and my EEG and CT came back normal, but my MRI showed up 4 lesions in my brain. I tested positive to ANA, and weakly positive to anti-DNA. I had a high titer of anticardiolipin antibodies in my blood as well. The neurologist diagnosed me with definate SLE, but my immunologist said it was only likely that I had SLE, and that the anticardiolipin was causing my problems?! The immunologist did more blood tests and it came back that was ANA was now only slightly raised and my Anti-DNA was now negative.
Is this normal or does this indicate that it isn't SLE? I have been trying to look up whether these values only increase during flare ups, but havent been able to find anything.
Also, I have been started on Plaquinil, but have since been extremely dizzy everyday (feeling almost like I am going to collapse) and I wanted to know if anyone knows if plaquinil would be causing that or if its just a coincidence, and if you even think this is the right medication for me.
I have felt very lost these past few weeks, and it seems nobody (the neurologist or immunologist) can give me a straight answer, or that they even understand each others perspective. :S I have already had 7 weeks off from work, and am still unsure if I can go back yet or not which means I am also broke (to add to my stress's!!) I would really appreciate it if somebody can give me some advice on what to do )
Will I have a hard time adopting?
My husband and I are considering adoption, but I am concerned that my health history will be an issue. I don't have anything majorly wrong with me, but I did suffer a stroke for unknown reasons in my early 20s. I do not have any deficiencies from the stroke at all. Recently they found elevated levels of anticardiolipin antibodies in me, which *may* have accounted for my stroke, but a lot of healthy people have high levels of these antibodies as well, and my elevated level could be transient (we will check my blood again at the end of the month to see).
It has been over 8 years since my stroke, but when people hear 'stroke' they think you have one foot in the grave already. I know the insurance companies see it that way.
Do you think this will be a major issue that will keep us from being able to adopt? I can have a baby of my own, but it would be considered high risk.
A lot of these answers are jumping to conclusions. I am not dying, I am extremely healthy and fit, my bloodwork comes back perfect. My main concern is people will see my history (past) and think I'm sick, because when people hear 'stroke' they think you have one foot in the grave.
As for having a child of my own, I'd be high risk. What good is having a child if something happens to it's momma? Just because someone is *fertile* doesn't mean they should have a baby.
I have a great home full of love, safety and opportunity for a child out there. What's wrong with so many of you that you'd rather they stay in the hands of the government than to have a family? Messed up, seriously.
My wife has a long medical history. She had major medical problems 20-25 years ago, and still takes medication daily and visits a doctor more in a month than I do in a year. She is basically healthy, in that she is able to work and function on a day-to-day basis; she just has chronic issues that have to be managed.
However, we were able to adopt from the foster care system without any significant problem. She was able to show that she is able to function and manage her medical problems.
You can expect to be asked about your medical history, but I really doubt they will disqualify you.
High Risk pregnancy ... Cardiolipin IgM value 45.0?
Cardiolipin-IgM value 45.0 Is it critical?
Cardiolipin abs-IgM - 45.0. Is it Critical?
Recently, i'd undergone the ANTICARDIOLIPIN antibodies test and the result is:CARDIOLIPIN Abs-IgM 45.0.
Do We need to worry about the baby? Is this Critical?
The doctor has suggested Inj.Clexane regularly.
* 16 hours ago
* - 3 days left to answer.
1 second ago
Any doctor here, pl. suggest whether Inj.Clexane need to taken regularly or we can take it weekly or so....
Recurrent miscarriage help!?
Okay, so I am looking for some answers ,any experience or advice would be great!
I have had 3 miscarriages.
The first stopped growing at about 6.5 weeks (I had a D&C at 11 weeks)
Second was natural at 5.5 weeks
Third was at 6wks, 4 days. D&C at 8 weeks.
My Dr. has ordered some test for my next cyle but they don't really seem to fit my medical history. I'm asking because My husband and I want to TTC instead of waiting another month to do tests.
The test he orderd are:
Lupus anticoagulant and anticardiolipin antibodies
TSH (thyroid-stimulating hormone )
I have no problem getting pregnant (1-2 months every time) and I have regular cycles (29 days).
What I mean is, are these test even worth waiting for? They doen't seem likely or they don't have a history and successful pregnancies with treatment. Also, can he do any of these test if I'm pregnant, like the insulin or progestrone?
those seem like normal test to be running he isn't worried about you getting pregnant it's about you being able to carry the baby full term
I have lost two pregnancies. What shall I do?
I am 25 years old. In February 2009 i had a miscarriage, i was about 8-9 weeks pregnant. The size of the embryo was 19mm.
After that, a month later(until 13.04.09) I Took the following test with results:
1) Immune status:
Anticardiolipin IgG -11,5 (lab norm 10)
Anticardiolipin IgM -37.2 (lab norm 10)
Antiphospholipid IgG -3.7 (lab norm 10)
Antiphospholipid IgM -8.8 (lab norm 10)
2) Analysis of hemostasis results were good
3) anti-CMV IgG (Cytomegalovirus) -7.5 (lab norms 0-0,5)
anti-CMV IgM -negative (norm - negative)
anti-T gondii IgG (Toxoplasma) -103.1 (norms 0-50)
anti-T godnii IgM (Toxoplasma) negative (norm - negative)
anti-HSV, type 1,2 IgG (herpes) -121.6 (norms 0-5.0)
anti-HSV, type 1,2 IgM (herpes) - negative (norm - negative)
5) Mycoplasmosis, ureoplasmosis - negative
6) Testosterone , prolactin, LH, FSH, T-4, TSH - normal
7) Antibody to rubella - negative
My doctor on thought it might be antiphospholipid syndrome.
7 months later, in September, we have decided to try to conceive again.
Ultrasound (12 October) - uterine pregnancy, the size of fetal egg 0,5 cm
Ultrasound (10 November) - the size of fetal egg 2,5 cm, CTE -0,9 ,detected heartbeat
Ultrasound (22 November) - an embryo is not visualized, the size of fetal egg 2,4 cm
Around week 6-7 the baby stopped developing (supposed to be 9 weeks)
23 November - surgical abortion, antibiotics.
During the pregnancy i did the following tests:
1) Anticardiolipin IgG: 18,0 (norm 0-48)
Anticardiolipin IgM: 17,2 (norm 0-44)
2) Lupus Anticoagulant - negative
Lupus Anticoagulant - negative
4) DHEA -3,0 (norm 0,9-3,6)
Tests results after clinical abortion:
anti-CMV IgG (CMV)-positive
anti-CMV IgM (CMV)-negative
anti-HSV, type 1,2 IgG (herpes) - positive
anti-HSV, type 1,2 IgM (herpes) - negative
If you could please advise me what i could do or what other tests there're to run?
What could be the reason of my pregnancies termination?
Thanks you a lot in advance
Looking forward to your response.
I had 2 doctors during my pregnancies,but one doctor refused to deal with my problem. Another doctor said, that my analysies are good and she saw no reason why miscarriages. On the beginning of the month I will go to genetics
Hi Natalia! I don't intend on reading this long chart, that's not what I come here for. Ask a live doctor what the reason is, not strangers on Yahoo Answers. I am sorry that you have herpes.
Sincerely, Hi Omg Omg Hi